It's too easy an explanation to just say race explains a lot of the election results, even considering the lopsided WV results. From the Newhouse News Service is something that may do a more thorough job at explaining a lot of things, not just the election results of late. See today's piece: Obama's Appalachian Problem
by Jonathan Tilove. Might also portend the VP slot, but who knows.
Largest city in Appalachia? Must be somewhere else right? Some stuff of note in the collected volume written not long ago: Pittsburgh and the Appalachians: Cultural and Natural Resources in a Postindustrial Age